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Unraveling Neurogenesis: The Intricacies of Adult Brain Renewal


Neurogenesis, the genesis of neurons, traditionally associated with fetal brain development, has long been believed to cease after infancy. Neuroscientist Ramón y Cajal’s work in 1928 reinforced this idea, asserting that no new neurons could be added to the adult brain post-fetal development (Paredes et al, 2016). However, recent studies have ignited a debate challenging this conventional wisdom, suggesting the possibility of neurogenesis in the adult human brain.

Examining the Evidence

Supporting Adult Neurogenesis

The most compelling study supporting adult neurogenesis involved autopsied hippocampi from individuals aged 14-79 (Boldrini et al, 2018). Surprisingly, the study revealed no significant differences in the total numbers of neural progenitors, immature neurons, glia, mature granule neurons, and dentate gyrus volume between age groups. These findings indicate the presence of new neurons in aging brains. The study’s strength lies in its use of unbiased stereology and samples from healthy individuals.

Disputing Adult Neurogenesis

Despite supporting evidence, skepticism persists. Some argue that neurogenesis might be less prevalent in larger brains due to anatomical limitations (Paredes et al, 2016). The longer migration distances of young neurons in larger brains and potential hindrances such as cortical tissue folding, contribute to the limited presence of new neurons in older brains.

Methodological Challenges

Critics often question studies involving postmortem tissue, such as one exploring hippocampal tissue from epilepsy patients (Kumar et al, 2019). While multiple validation methods were employed, concerns linger regarding the destruction of the neurogenic niche in severe epilepsy, possibly influencing neurogenesis findings. Methodological considerations, including fixation processes, also impact the reliability of results (Terstege et al, 2022).

Factors Influencing Adult Neurogenesis

Understanding the nuances of adult neurogenesis involves considering various factors, both intrinsic and extrinsic.

Intrinsic Factors

Hormones, Trophic Factors, Glia, and Vasculature play crucial roles in creating a neurogenic niche that significantly influences neural stem cell proliferation and overall brain plasticity.

Trophic Factors

Trophic factors such as Brain-Derived Neurotrophic Factor (BDNF), Fibroblast Growth Factor (FGF), and Epidermal Growth Factor (EGF) are essential elements in the intricate orchestration of neural processes. These factors contribute significantly to cell growth, proliferation, maturation, and the long-term maintenance of neurons (Shohayeb et al., 2018). The research underscores the importance of these trophic factors in shaping the structural and functional aspects of neural circuits.

Neurotransmitters

Neurotransmitters serve as the chemical messengers of the nervous system, mediating neuronal communication and playing a pivotal role in shaping various cognitive functions. Glutamate, Gamma-Aminobutyric Acid (GABA), Acetylcholine (Ach), dopamine, and serotonin are key neurotransmitters that influence mood, learning, and memory (Shohayeb et al., 2018). The balance and modulation of these neurotransmitters are critical for maintaining optimal cognitive function, and imbalances can lead to various neurological and psychiatric disorders.

Hormones

Hormones, particularly sex hormones, have been implicated in modulating neural plasticity and cognitive processes (Shohayeb et al., 2018). The study highlights the association between sex hormones and increased learning as well as cell growth. Estrogen, progesterone, and testosterone, among others, play intricate roles in shaping the neural landscape, influencing synaptic connectivity, and promoting neurogenesis in specific brain regions.

Glia

Glia, often referred to as the support cells of the nervous system, play multifaceted roles in neural function. Astrocytes, microglia, and oligodendrocytes are types of glial cells that contribute to the maintenance of homeostasis, synaptic connectivity, and myelination, respectively. Beyond their traditional supportive roles, emerging research suggests that glial cells actively participate in modulating synaptic transmission and plasticity, further emphasizing their importance in intrinsic factors governing neural processes.

Vasculature

The vascular system, responsible for supplying oxygen and nutrients to the brain, is a critical intrinsic factor in neural function. Adequate blood flow is essential for maintaining the energy demands of active neurons and supporting neurogenesis (Shohayeb et al., 2018). Disruptions in vascular function can lead to compromised cognitive abilities and contribute to neurodegenerative diseases.

Understanding the interplay between these intrinsic factors provides valuable insights into the complex mechanisms that govern neural plasticity. Further research in this field holds the potential to unveil new therapeutic targets for neurodevelopmental and neurodegenerative disorders, offering innovative approaches to enhance cognitive function and promote brain health.

Extrinsic Factors

Environmental Enrichment

Environmental factors play a significant role in influencing neural plasticity. In animal studies, it has been demonstrated that physical activity, mating, and access to food can enhance hippocampal neurogenesis (Kumar et al., 2019). These enriching experiences create a positive impact on the brain, fostering the growth and development of new neurons in the hippocampus.

Stress

Stress, both acute and chronic, has been shown to have detrimental effects on neurogenesis, highlighting the profound impact of external factors on the brain (Kumar et al., 2019). The research underscores the importance of stress management and its potential role in preserving or enhancing neurogenic processes in the brain.

Diet

Dietary choices have a profound influence on cognitive function and neuroplasticity. Diets rich in polyunsaturated fatty acids and polyphenols have been found to promote neuronal plasticity, supporting the growth and maintenance of neurons (Shohayeb et al., 2018). Conversely, diets high in saturated fats and sugars have been associated with a reduction in cognitive functioning, underscoring the importance of a balanced and nutrient-rich diet for optimal brain health.

Understanding how environmental factors, stress, and diet impact neural plasticity provides valuable insights into potential avenues for promoting cognitive well-being. Incorporating lifestyle changes that foster environmental enrichment, stress reduction, and a healthy diet may offer effective strategies for enhancing neurogenesis and overall brain function.

Clinical Implications of Adult Neurogenesis

Understanding the implications of adult neurogenesis is indeed crucial for reshaping our approach to brain-related diseases and disorders, as it challenges traditional notions of the static adult brain and opens up new possibilities for therapeutic interventions.

Memory and Learning Systems

The role of neurogenesis in memory and learning systems challenges the conventional belief in the fixed nature of the adult brain. Research, as highlighted by Kumar et al. in 2019, suggests that neurogenesis contributes to cognitive processes such as memory formation and learning. The continuous generation of new neurons in specific brain regions, particularly the hippocampus, introduces a dynamic aspect to the adult brain, emphasizing its capacity for adaptation and plasticity.

Neuropsychiatric Disorders and Age-Related Dysfunctions

The absence or reduction of neurogenesis has been linked to various neuropsychiatric disorders and age-related dysfunctions. Conditions such as epilepsy, stroke, stress, depression, schizophrenia, and Alzheimer’s Disease have been associated with compromised neurogenic processes. Understanding the role of neurogenesis in these disorders provides insights into potential targets for therapeutic interventions, offering new avenues for developing treatments that address the underlying neural mechanisms.

Treatment Strategies

The recognition of neurogenesis as a dynamic process in the adult brain opens up innovative possibilities for treatment strategies. Interventions aimed at stimulating neurogenesis, such as through exercise, nutrition, and adequate sleep, could revolutionize the approach to cognitive disorders. Kumar et al. (2019) suggest that lifestyle modifications and interventions that promote neurogenesis may serve as effective and holistic strategies for enhancing cognitive function and mitigating the impact of neurodegenerative diseases and psychiatric disorders.

In conclusion, while the debate on adult neurogenesis persists, evidence supporting its presence is compelling. Unraveling the intricacies of neurogenesis opens new avenues for understanding brain function and developing innovative clinical interventions. As we navigate the complexities of this evolving field, one thing is clear: the adult brain may possess more regenerative potential than previously imagined.

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